Dried blood spots in therapeutic drug monitoring and toxicology
نویسندگان
چکیده
منابع مشابه
Therapeutic drug monitoring in dried blood spots using liquid microjunction surface sampling and high resolution mass spectrometry.
Dried blood spots (DBS) are a versatile and stable tool for direct clinical blood analysis. Ambient high-resolution mass spectrometry is emerging as a method of choice for their quantitative analysis, for instance in therapeutic drug monitoring. Here, we coupled liquid microjunction surface sampling technology, a so-called Flowprobe, with an Orbitrap mass spectrometer and demonstrated the utili...
متن کاملUse of Therapeutic Monitoring in Drug Monitoring and Toxicology (dmt)
1. Reinshagen M, Schutz E, Armstrong VW, Behrens C, von Tirpitz C, Stallmach A, et al. 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active Crohn disease: results from a randomized, controlled, open trial. Clin Chem 2007;53:1306–14. 2. Shipkova M, Armstrong VW, Wieland E, Oellerich M. Differences in nucleotide hydr...
متن کاملDrieD BlooD SpotS
The multi-region hybridization assay (MHAbce) for genotyping HIV-1 subtypes B, C and circulating recombinant form (CRF01_AE) was evaluated on paired plasma and dried blood spots (DBS) collected from 68 HIV-1 infected individuals in Thailand. CRF01_AE was the predominant subtype identified using plasma samples (51/62) and DBS (24/27). There was no discordance in subtype designations between plas...
متن کاملTherapeutic drug monitoring of antiretroviral drugs at home using dried blood spots: a proof-of-concept study.
BACKGROUND In HIV-infected patients, therapeutic drug monitoring (TDM) of antiretroviral drugs is recommended in special populations and in specific situations to optimize therapy. Currently, TDM is performed via measurement of drug plasma concentrations; however, dried blood spots (DBS) may offer a patient friendly and cost-effective alternative. Therefore, this proof-of-concept study assessed...
متن کاملAcceptance of domiciliary theophylline monitoring using dried blood spots.
Filter paper cards incorporating dried blood spots for the measurement of theophylline concentrations were returned by 62 out of 100 asthmatic children sent kits with instructions for their collection. Analysis of the blood spots showed that 37 (61%) of the children who returned them had less than therapeutic blood theophylline concentrations, in 21 (34%) they were therapeutic, and in three (5%...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Metabolism & Toxicology
سال: 2017
ISSN: 1742-5255,1744-7607
DOI: 10.1080/17425255.2018.1414181